刘志博

教授，博士生导师，国家杰出青年基金获得者

放射性药物化学·放射化员工物学

永利集团 77779193永利集团
永利集团北大-清华生命科学联合中心
电子信箱：zbliu@pku.edu.cn
课题组网站：http:/zliu/

研究兴趣：

活体化学及其驱动的蛋白激活及药物释放；
罕见病的影像诊断探针及临床转化研究；
中子捕获治疗药物及其辐射生物学效应;
新型医用核素的生产工艺研究与临床应用。

奖励与荣誉:

2021, Best Preclinical Publication Award, the 9^th World ADC Annual Meeting
2021, Ones-to-Watch, Society of Nuclear Medicine and Molecular Imaging
2020, 中国化学会青年化学奖
2019, 药明康德生命化学青年学者奖
2019, 永利集团青年教师教学基本功大赛一等奖
2018, Fairchild Award, 18th International Congress of Neutron Capture Therapy
2018, 永利集团绿叶生物青年科学家奖
2016, Distinguished Scientist Award, NIH-CSSA Committee
2015, Michael J. Welch Postdoctoral Award, Society of Nuclear Medicine and Molecular Imaging
2015, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
2015, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
2014, Edward Piers Memorial Award, Edward Piers Foundation
2014, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
2013, Young Investigator Award, 37th CASNMMI
2013, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation

代表性论文：

Qinyang Wang^#, Yupeng Wang^#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426
Zhibin Guo^#, Hanyu Hong^#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, doi: 10.1002/anie.202205014.
Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8,837
Jiyuan Li^#, Qi Sun^#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat Commun, 2022, 13, 2143
Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*, Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors, J. Am. Chem. Soc., 2022, doi.org/10.1021/jacs.2c02521
Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, Cationic Micelle as An In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 60, 19750–19758
Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255
Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552
Pu Zhang^#, Mengxin Xu^#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996
Mengxin Xu^#, Pu Zhang^#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2021, doi: 10.2967/jnumed.121.262533