Total Syntheses of (-)-Huperzine Q, (+)-Lycopladines B and C

Congratulations to Benke, Houhua, Jinbao and Jing for their latest total synthesis published on ACIE! Angew. Chem. Int. Ed. 2014 , DOI: 10.1002/anie.201409503 Abstract: Utilizing a late-stage enamine bromofunctionlization strategy, we have accomplished a 12-step total synthesis of (-)-huperzine Q as well as the first total syntheses of (+)-lycopladines B and C. We also report […]

Congratulations to Benke, Houhua, Jinbao and Jing for their latest total synthesis published on ACIE!

Angew. Chem. Int. Ed. 2014 , DOI: 10.1002/anie.201409503

Abstract:

Utilizing a late-stage enamine bromofunctionlization strategy, we have accomplished a 12-step total synthesis of (-)-huperzine Q as well as the first total syntheses of (+)-lycopladines B and C. We also report an unprecedented X-ray crystal structure of an unusual epoxyamine intermediate and demonstrate its useful synthetic application in natural product synthesis.

?