Xiaoguang Lei,Ph.d
Department of Chemical Biology
College of Chemistry and Molecular Engineering, Peking University,
Beijing 100871, P. R. China
Address
Room C518,
College of Chemistry and Molecular Engineering,
Peking University, Beijing, 100871, China
Contact
Tel: +86-10-6276-0292
Web:http:/leigroup/
Email：xglei@pku.edu.cn
Education
2001 – 2006 Ph.D. in Organic Synthesis and Chemical Biology Boston University, Boston, USA
Advisor: Professor John A. Porco, Jr.
Thesis: “Target and Diversity-Oriented Synthesis Using Epoxyquinoid Scaffolds”
1997 – 2001 B.S. in Chemistry Peking University, Beijing, China
Advisor: Professor Jianbo Wang
Professional Experience
2014 – Current Professor, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, China
2008 – 2014 Principal Investigator and Director of Chemistry Center, National Institute of Biological Sciences (NIBS), Beijing, China
2010 – 2013 Professor, College of Pharmaceutical Science and Technology, Tianjin University
2008 – 2010 Associate Professor, College of Pharmaceutical Science and Technology, Tianjin University, China
2006 – 2008 Post-doctoral Fellow, Bioorganic Chemistry, Columbia University and Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Advisor: Professor Samuel J. Danishefsky
Honors and Awards
- The Sackler Chair Award，2023
- MDPI Tu Youyou Award, 2022
- Xplorer Prize, 2022
- Boehringer-Ingelheim Senior Faculty Research Award, 2021
- Novartis Most Valuable Partner Award, 2021
- Sackler Chair Visiting Scholar Award, Israel, 2021
- Bayer Investigator Award, 2020
- Shu Lan Young Medical Investigator Award, 2019
- David Ginsburg Memorial Lectureship Award, Israel, 2018
- CCS-BASF Young Investigator Award, 2018
- Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry, 2017
- Swiss Chemical Society Distinguished Lectureship Award, Switzerland, 2017
- KAIST School of Molecular Science Lectureship Award, South Korea, 2017
- Asian Core Program Lectureship Award, 2016
- Organic Chemistry Frontier Emerging Investigator Award, 2016
- National Distinguished Young Investigator Award, 2016
- Wei Shan Natural Product Synthesis Award by Chinese Chemical Society, 2015
- Chemical Society of Japan Distinguished Lectureship Award, 2015
- Outstanding Young Talent Award of Beijing, 2014
- Roche Young Investigator Award, 2014
- National Leading Young Scientific Investigator Award, 2013
- Chinese Chemical Society Prize for Young Scientists, 2013
- Young Chemical Biologist Award by the International Chemical Biology Society (ICBS), 2013
- Servier Young Investigator Award by Chinese Pharmaceutical Association, 2013
- Thieme Chemistry Journal Award, 2013
- Asian Core Program Lectureship Award, 2012
- Outstanding Young Investigator Award by National Natural Science Foundation of China, 2012
- New Century Excellent Talents in University Award, 2010
- WuXi PharmaTech 2010 Life Science and Chemistry Award, 2010
- IUPAC Young Chemist Award, 2009
- NESACS-JCF/GDCh Exchange Scholarship to Germany, 2005
- Travel Award for the Gordon Research Conference on Combinatorial Chemistry, 2005
- Sugata Ray Memorial Award for Excellence in Research and Teaching at Boston University,
Affiliation
- Member, International Chemical Biology Society (ICBS)
- Member, Chinese-American Chemistry Professor Association (CAPA)
- Member, American Chemical Society
- Member, Chinese Chemical Society
- Member, Chinese Pharmaceutical Association
Professional Service
Editor, Bioorganic and Medicinal Chemistry, 2017
Editorial Board Member, Bioorganic and Medicinal Chemistry (Letters), 2016-
Editorial Board Member, Advanced Science, 2015-
Editorial Board Member, Natural Product Research and Development, 2015-
Manuscript Referee
Nature (April 2020–Present)
Nature Chemical Biology (March 2013–Present)
Nature Cell Biology (April 2014–Present)
Nature Communication (October 2013–Present)
Cell Chemical Biology (September 2015–Present)
Angewandte Chemie, International Edition (July 2008–Present)
Chemical Communications (August 2008–Present)
Chemistry: A European Journal (December 2008–Present)
Chemistry: An Asian Journal (March 2009–Present)
European Journal of Organic Chemistry (November 2008–Present)
Organic and Biomolecular Chemistry (January 2010–Present)
Organic Letters (October 2008–Present)
Journal of the American Chemistry Society (August 2011–Present)
Journal of Organic Chemistry (January 2010–Present)
Research Interests
- Chemical biology
- Natural product synthesis
- Synthetic biology
- Drug discovery
Publications
- Jiang B, Gao L, Wang H, Sun Y, Zhang X, Ke H, Liu S, Ma P, Liao Q, Wang Y, Wang H, Liu Y, Du R, Rogge T, Li W, Shang Y, Houk KN, Xiong X, Xie D, Huang S, Lei X*, Yan J*. Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Science. 2024 Feb9;383(6683):622-629. doi: 10.1126/science.adj3484. Epub 2024 Jan 25. PMID:38271490.
- Dong, H., Guo, N., Hu, D., Hong, B., Liao, D., Zhu, H.J., Yan, Z.Y., Ge, H.M., and Lei, X. (2024). Chemoenzymatic total synthesis of alchivemycin A. Nature Synthesis 3, 1124-1133. 10.1038/s44160-024-00577-7.
- Kai Wang, Zhiwei Zhang, Jing Hang, Jia Liu, Fusheng Guo, Yong Ding, Meng Li, Qixing Nie,Jun Lin, Yingying Zhuo, Lulu Sun, Xi Luo, Qihang Zhong, Chuan Ye, Chuyu Yun, Yi Zhang, Jue Wang,Rui Bao, Yanli Pang, Guang Wang*, Frank J. Gonzalez*, Xiaoguang Lei*, Jie Qiao*, Changtao Jiang*”Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target”Science, 2023, 381(6657), eadd5787
- Wang S, Chen K, Guo F, Zhu W, Liu C, Dong H, Yu JQ, Lei X. C-H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors. ACS Cent Sci. 2023 Jun 9;9(6):1129-1139. doi: 10.1021/acscentsci.3c00201. PMID:37396867; PMCID: PMC10311666.
- Fan J, Hu L, Yue Z, Liao D, Guo F, Ke H, Jiang D, Yang Y, Lei X. Structural basis of TRPV3 inhibition by an antagonist. Nat Chem Biol. 2023 Jan;19(1):81-90.doi: 10.1038/s41589-022-01166-5. Epub 2022 Oct 27. PMID: 36302896.
- Junxia Zhang, Ruqi Liang, Kai Wang, Wenjia Zhang, Mao Zhang, Li Jin, Peng Xie, Wen Zheng, Haibao Shang, Qingmei Hu, Jiayi Li, Gengjia Chen, Fujian Wu, Feng Lan, Lipeng Wang, Shi-Qiang Wang, Yongfeng Li, Yong Zhang, Jinghao Liu, Fengxiang Lv, Xinli Hu, Rui-Ping Xiao, Xiaoguang Lei*, Yan Zhang* “Hesperadin Is a Novel CaMKII-δ Inhibitor and Exerts Dual Functions to Both Protect Cardiac Ischemia/reperfusion Injury and Inhibit Tumor Growth” Circulation 2022, 145, 1154-1168
- Jianyong Du, Lixia Zheng, Peng Gao, Hang Yang, Wan-Jie Yang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, Linlu Bai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu, Zhixing Chen, Liangyi Chen, Ke Wei, Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao*, Xiaoguang Lei*, Jing-Wei Xiong* “A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration” Cell Stem Cell 2022, 29, 545-558
- Lei Gao, Yike Zou, Xiaojing Liu, Jun Yang, Xiaoxia Du, Jin Wang, Xinshui Yu, Junping Fan, Mingxuan Jiang, Yuli Li, K. N. Houk*, Xiaoguang Lei* “Enzymatic control of endo and exo stereoselective Diels-Alder reactions with broad substrate scope” Nature Catalysis 2021, 4, 1059-1069
- Gao L, Su C, Du X, Wang R, Chen S, Zhou Y, Liu C, Liu X, Tian R, Zhang L, Xie K, Chen S, Guo Q, Guo L, Hano Y, Shimazaki M, Minami A, Oikawa H, Huang N, Houk KN, Huang L, Dai J, Lei X. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat Chem. 2020 Jul;12(7):620-628. doi: 10.1038/s41557-020-0467-7. Epub 2020 May 25. PMID: 32451436.
- Benke Hong†, Weilong Liu†, Jin Wang†, Jinbao Wu, Yuichiro Kadonaga, Pei-Jun Cai, Hong-Xiang Lou, Zhi-Xiang Yu, Houhua Li*, and Xiaoguang Lei*, Photoinduced skeletal rearrangements reveal radical-mediated synthesis of terpenoids, Chem 2019, 5, 1671-1681