Total Synthesis of the Diazobenzofluorene Antibiotic (-)-Kinamycin C1
Xiaoguang Lei and John A. Porco, Jr.
J. Am. Chem. Soc. 2006 , 128 , 14790-14791( News story describing this work was highlighted in Chem. & Eng. News 2006 , 45 , 9. )
The enantioselective total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C is reported. The approach involves tartrate-mediated, asymmetric nucleophilic epoxidation of a functionalized quinone monoketal to construct the highly substituted D-ring.
