Xiaoguang Lei, Samuel J. Danishefsky
Adv. Synth. Catal. 2008 , 350, 1677-1681
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol, is described. The key step involves a fragment coupling using ‘click chemistry’ The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol, is described. The key step involves a fragment coupling using ‘click chemistry’ The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.