Efficient Generation of ortho -Quinone Methide: Application to the Biomimetic Syntheses of (±)-Schefflone and Tocopherol Trimers
Daohong Liao, Houhua Li and Xiaoguang Lei*
Org. Lett. 2012, 14, 18-21
An efficient method using silver oxide-mediated oxidation for the synthesis of?ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported. View Full Article
An efficient method using silver oxide-mediated oxidation for the synthesis of?ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported.