Synthesis and mode of action of oligomeric sesquiterpene lactones

Chao Li, Alexander Jones, and Xiaoguang Lei
Nat. Prod. Rep. , 2015, DOI: 10.1039/C5NP00089K

Abstract: In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (?)-ainsliatrimer A (5). Ainsliadimer A possesses potent anti-inflammatory activity by inhibition of the NF-κB signalling pathway?via?binding at a previously untargeted allosteric site. (?)-Ainsliatrimer A induces […]

Abstract:

In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (?)-ainsliatrimer A (5). Ainsliadimer A possesses potent anti-inflammatory activity by inhibition of the NF-κB signalling pathway?via?binding at a previously untargeted allosteric site. (?)-Ainsliatrimer A induces apoptosis in cancer cells by activation of PPARγ. Furthermore, we highlight a new bioorthogonal ligation (TQ-ligation) developed in our laboratory which facilitates the target identification of complex natural productsvia?pre-target fluorescence imaging and affinity chromatography. Generally, this paper will discuss the complete process from total synthesis to biological studies of complex natural products, and from the establishment of new bio-orthogonal chemistry to successful target identification. Our approach provides a systematic and efficient methodology for addressing the challenge of natural product target identification.

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00089K