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 Covalent Probe Finds Carboxylic Acid

Jones, A.; Zhang, X.; Lei, X.*
Cell Chem. Biol. 2017, 24, 537-538

In this issue of Cell Chemical Biology, Mart?′n-Gago et al. (2017a) disclose a new strategy for the selective covalent?targeting of binding site carboxylic acids within the proteome using the isoxazolium salt as a warhead.?This discovery paves the way for developing newprotein ligation methods as well as covalent drug candidates. http://www.cell.com/cell-chemical-biology/pdf/S2451-9456(17)30143-5.pdf

In this issue of Cell Chemical Biology, Mart?′n-Gago et al. (2017a) disclose a new strategy for the selective covalent?targeting of binding site carboxylic acids within the proteome using the isoxazolium salt as a warhead.?This discovery paves the way for developing newprotein ligation methods as well as covalent drug candidates.

http://www.cell.com/cell-chemical-biology/pdf/S2451-9456(17)30143-5.pdf