Yongqi Huang

Physical Chemistry, Peking University
Grad. 2007-2012
Research Area: Binding property of Intrinsically disordered proteins
Email: yqhuang_at_pku.edu.cn

Experiences:

2007.9-2012.7, Ph.D. in Chemistry, Peking University

2012.9-2015.10, Postdoc. in St. Jude Children's Research Hospital

2016.1-2016.9, Assistant Professor in Shandong University

2016.10-*, Associate Professor in Hubei University of Technology

Publications:

1. Huaiqing Cao, Yongqi Huang*, and Zhirong Liu*. Interplay between binding affinity and kinetics in protein-protein interactions. Proteins: Struct. Funct. Bioinform. 84 (7), 920-933 (2016).

2. Zhirong Liu and Yongqi Huang. Advantages of proteins being disordered. Protein. Sci. 23 (5), 539-550 (2014). (invited review)

3. Yongqi Huang and Zhirong Liu. Do intrinsically disordered proteins possess high specificity in protein–protein interactions? Chem. Eur. J. 19 (14), 4462-4467 (2013).

4. Zhirong Liu and Yongqi Huang. Evidences for the unfolding mechanism of three-dimensional domain swapping. Protein Sci. 22 (3), 280-286 (2013).

5. Yongqi Huang, Xue Kang, Bing Xia, and Zhirong Liu. Mechanism of 3D domain swapping for Mpro-C: clues from molecular simulations. Acta Phys. -Chim. Sin. 28 (10), 2411-2417 (2012).

6. Iskra Staneva, Yongqi Huang, Zhirong Liu, and Stefan Wallin. Binding of two intrinsically disordered peptides to a multi-specific protein: a combined Monte Carlo and molecular dynamics study. PLoS Comput. Biol. 8 (9), e1002682/1-9 (2012).

7. Yongqi Huang, Huaiqing Cao, and Zhirong Liu. Three-dimensional domain swapping in the protein structure space. Proteins: Struct. Funct. Bioinform. 80 (6), 1610-1619 (2012).

8. Yongqi Huang and Zhirong Liu. Anchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein. Int. J. Mol. Sci. 12 (2), 1410-1430 (2011).

9. Yongqi Huang and Zhirong Liu. Nonnative interactions in coupled folding and binding processes of intrinsically disordered proteins. PLoS ONE 5 (11), e15375/1-10 (2010).

10. Yongqi Huang and Zhirong Liu. Smoothing molecular interactions: the "kinetic buffer" effect of intrinsically disordered proteins. Proteins: Struct. Funct. Bioinform. 78 (16), 3251-3259 (2010).

11. Yongqi Huang and Zhirong Liu. Intrinsically disordered proteins: the new sequence-structure-function relations. Acta Phys. -Chim. Sin.26 (8), 2061-2072 (2010).

12. Yifei Qi*, Yongqi Huang*, Huanhuan Liang, Zhirong Liu, and Luhua Lai. Folding simulations of a de novo designed protein with a βαβ fold. Biophys. J. 98 (2), 321-329 (2010).

13. Yongqi Huang and Zhirong Liu. Kinetic advantage of intrinsically disordered proteins in coupled folding-binding process: a critical assessment of the "fly-casting" mechanism. J. Mol. Biol. 393 (5), 1143-1159 (2009). [422 (1), 156 (2012).]

14. Yongqi Huang, Huifang Li, and Yuxiang Bu. Molecular dynamics simulation exploration of cooperative migration mechanism of calcium ions in sarcoplasmic reticulum Ca²⁺-ATPase. J. Comput. Chem. 30 (13), 2136-2145 (2009).

Meetings:

1. Yongqi Huang, Nonnative Interactions in Coupled Folding and Binding Processes of Intrinsically Disordered Proteins. Poster. Barcelona BioMed Conference on "Intrinsically disordered proteins in biomedicine", Barcelona, Spain. October 4-6, 2010.

2. Yongqi Huang and Zhirong Liu, Nonnative Interactions in the Binding Process of Intrinsically Disordered Proteins: Implication for Interaction Promiscuity and Aggregation. Poster + short talk. The 3rd Asia Pacific Protein Association (APPA) Conference, Shanghai University, Shanghai, China. May 6-9, 2011.

3. Yongqi Huang, Xue Kang, Bin Xia, and Zhirong Liu, Unfolding simulation of C-terminal domain of SARS-CoV main protease: the swapping core helix. Poster. The 25th Anniversary Symposium of the Protein Society, Boston, Massachusetts, U.S.A., July 23-27, 2011.

Awards:

1. 2012 Excellent doctorate dissertation, College of Chemistry and Molecular Modeling, Peking University

2. 2011 The Protein Society Finn Wold Travel Award, The Protein Society, USA

3. 2011 Zhong-Chen-Yu-Lan Scholorship, Peking University

4. 2010 Eastern Havour Scholorship, Peking University

5. 2009 Suzhou Industrial Park Scholorship, Peking University

6. 2009, 2010, 2011: Fellowship of Center for Theoretical Biology, Peking University, China