Wgroup
member: Zhihua Ma
Graduate student ()
Dr. Zhihua Ma's project was the development of new synthetic methods for chiral beta-amino acids. He discovered highly diastereoselective addition of lithium enolate to N-tosyl amine, which could lead to the synthesis of Enantiomerically pure beta-aryl-beta-amino acids. Dr. Ma has joined Professor M. P. Sibi's group in University of North Dakota as a postdoctoral fellow.
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Ph.D thesis: Asymmetric Synthesis
of beta–Amino Acids
Publications
(1) Stereoselective Nucleophilic Addition of Chiral Lithium Enolates
to (N-Tosyl)imines: Enantioselective Synthesis of b-Aryl-b-amino
Acid Derivatives
Zhihua Ma, Yonghua Zhao, Nan Jiang, Xianglin Jin, Jianbo Wang Tetrahedron
Lett. 2002, 43, 3209-3212. Click
Here
(2) Diastereoselective a-Alkylation of
b-Amino Esters: Preparation of Novel
a-Substituted b-Amino
Esters from a-Amino Acids
Zhihua Ma, Cong Liu, Yonghua Zhao, Wei Li, Jianbo Wang Chin Chem
Lett. 2002, 13, 721-724. Click
Here
(3) Recent Development in Asymmetric Synthesis of b-Amino
Acids (A review in Chinese)
Zhihua Ma, Yonghua Zhao and Jianbo Wang, Chin. J. Org. Chem. 2002,
22, 807-816. Click
Here
(4) Catalytic Asymmetric [2,3]-Sigmatropic Rearrangement of Sulfur
Ylides generated from Copper(I) Carbenoids and Allyl Sulfides
Xiaomei Zhang, Zhaohui Qu, Zhihua Ma, Weifeng Shi, Xianglin Jin and
Jianbo Wang, J. Org. Chem. 2002, 67, 5621-5625.
Click Here
(5) Investigation on the Transition Metal and Acid Catalyzed Reaction
of b-(N-Tosyl)amino Diazo Carbonyl
Compounds
Nan Jiang, Zhihua Ma, Zhaohui Qu, Xiaoyu Xing, Linfeng Xie and Jianbo
Wang J. Org Chem. 2003, 68, 893-900. Click
Here
(6) Rh2(OAc)4-Mediated Diazo Decomposition of d-(N-Tosyl)amino-b-keto-a-diazo
Carbonyl Compounds: An Novel Approach to Pyrrole Derivatives
Guisheng Deng, Nan Jiang, Zhihua Ma, Jianbo Wang, Synlett,
2002, 1913-1915. Click
Here
(7) A Highly Stereoselective Addition of the Anion Derived from a-Diazoacetamide
to Aromatic (N-Tosyl)imines
Yonghua Zhao, Zhihua Ma, Xiaomei Zhang, Yaping Zou, Xianglin Jin and
Jianbo Wang
Angew. Chem. Int. Ed. 2004, 43,
5977-5980. Click
here.