Xinyuan Fan

PhD, Research Associate Professor

Email：xinyuanfan@pku.edu.cn

Education and Experience

2019-present, Research Associate Professor, Peking University
2017-2019, Associate Professor, Nanjing Tech University
2015-2017, Postdoctoral Fellow, Peking University
2010-2014, PhD, Institute of Chemical Research of Catalonia, Tarragona, Spain
2013-2013, Visiting scholar, University of Pennsylvania, Philadelphia, USA
2003-2010, B.S & M.S., Lanzhou University, Lanzhou, China

Research Interests

Chemical biology, bioorthogonal photocatalysis, bioorthogonal chemistry, photocatalytic chemistry, proteomics

Selected Publications:

Area 1: Bioorthogonal chemistry for protein regulation
1. Zhu, Y.#, Ding, W.#, Fan, X.*, Lin, S.*, Chen, P.*, Genetically encoded bioorthogonal tryptophan decaging in living cells. Nat. Chem. 2024, 16 (4), 533-542.
2. Zhang, X.#; Huang, H.#; Liu, Y.; Wu, Z.; Wang, F.; Fan, X.*; Chen, P.*; Wang, J.*, Optical Control of Protein Functions via Genetically Encoded Photocaged Aspartic Acids. J. Am. Chem. Soc.2023, 145, 19218–19224.
3. Ngai, W. S. C.#; Yang, S.#; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.; Fan, X.*; Chen, P.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis. J. Am. Chem. Soc. 2022, 144 (12), 5411-5417.
4. Wang J.#; Wang X.#; Fan, X.*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems. ACS Cent. Sci. 2021 7 (6), 929-943.
5. Wang, X.#; Liu, Y.#; Fan, X.#; Wang, J.; Ngai, W. S. C.; Zhang, H.; Li, J.; Zhang, G.; Lin, J.*; Chen, P.* “Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications”, J. Am. Chem. Soc. 2019, 141 (43), 17133.
Area 2: Photocatalytic chemistry for molecule construction
1. Guo, F.#; Shan, S.#; Gong, X.#; Dai, C.; Quan, Z.*; Cheng, X.*; Fan, X.*, Deuteration Degree-Controllable Methylation via a Cascade Assembly Strategy using Methylamine-Water as Methyl Source. Chem. Eur. J. 2023, e202301458.
2. Zhu, J.#; Dai, C.#; Ma, M.; Yue, Y.; Fan, X.*, Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines. Org. Chem. Front. 2021, 8 (6): 1227-32.
3. Lizandara-Pueyo, C.*; Fan, X.*; Ayats, C.; Pericàs, M. A., Calcium carbonate as heterogeneous support for recyclable organocatalysts. J. Catal. 2021, 393, 107-115.
4. Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis”, Org. Lett.2019, 21 (1), 27-31.
5. Fan, X.*; Gong, X.; Ma, M.; Wang, R.; Walsh, P. J.* “Visible Light-Promoted CO2 Fixation with Imines to Synthesize Diaryl α-Amino Acids”, Nat. Commun.2018, 9(1), 4936.
6. Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Visible Light-Mediated Umpolung Reactivity of Imines: Ketimine Reductions with Cy2NMe and Water”, Org. Lett. 2018, 2433.
7. Fan, X.; Walsh, P. J.* “Chelation-Controlled Additions to Chiral α- and β-Silyloxy, α-Halo, and β-Vinyl Carbonyl Compounds”, Acc. Chem. Res. 2017, 50, 2389.
Area 3: Bioorthogonal photocatalysis for spatiotemporal control
1. Liu, Z.#; Guo, F.#; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen, P.*; Fan, X.*, “Bioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples.” Nat. Commun. 2024, 15 (1), 2712. (CAT-S technique)
2. Zhang, Y.; Liu, S.; Guo, F.; Qin, S.; Zhou, N.; Fan, X.*; Chen, P.*, Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling. J. Am. Chem. Soc.2024, 146, DOI: 10.1021/jacs.4c02052. (CAT-Cell technique)
3. Guo, F.#; Qin, S.#; Liu, Z.#; Chen, P.*; Fan, X.*, Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling. Bioorg. Chem.2024, 143, 107088.
4. Liang, X.#; Qian, S.#; Lou, Z.; Hu, R.; Hou, Y.; Chen, P.*; Fan, X.*, Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice. Angew. Chem. Int. Ed. 2023, e202310920. (CAT-NIR technique)
5. Liu, Y.; Ge, Y.; Zeng, R.; Ngai William Shu, C.; Fan, X.*; Chen, P.*, Proximity Chemistry in Living Systems. CCS Chem. 2023, 5, 802-813.
6. Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.; Fan, X.*; Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging. Chem 2022, 8, 2179–2191. (CAT-Ex technique)
7. Luo, H.#; Tang, W.#; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.; Fan, X.*; Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells. Angew. Chem. Int. Ed. 2022, 61 (27), e202202008.
8. Huang, Z.#; Liu, Z.#; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. J. Am. Chem. Soc. 2021, 143 (44), 18714-18720. (CAT-Prox technique)