Research News, July 23rd, 2009
Zirconocene-mediated ligand-switched selective cleavage of active and inert carbon-carbon bonds in allylcyclopropanes
Chao Wang, Liang Deng, Jun Yan, Hailin Wang, Qian Luo, Wen-Xiong Zhang and Zhenfeng Xi*
Chem. Commun., 2009, 4414-4416.
In this paper, we have developed a novel zirconium (II)-mediated ligand-controlled selective cleavage of different C–C bonds in bromoallylcyclopropane, which contains multiply reactive sites. This reaction represents a new way leading to selective cleavage of both reactive and inert C–C bonds.
本论文主要研究了低价有机锆试剂促进的多取代环丙烷的开环反应。在反应中对锆的配体进行调控后，惰性的环丙烷侧链碳碳键可以被切断，而活泼的三元母环却可以保持。碳碳键活化以其重要性和高难度被称为化学的圣杯。本部分的工作初步体现了一类新型的碳碳键活化过程。