报告摘要

Ultrafast 2D spectroscopies interrogate structure through cross peaks that measure the couplings between molecules.  2D Infrared spectroscopy measures vibrational couplings and 2D White-Light (or Visible) spectroscopy probes electronic couplings. This talk will present results utilizing 2D Infrared spectroscopy to study the aggregation pathway of the amylin protein involved in type 2 diabetes.  Using the structural information derived from that system, we have been able to trap a cytotoxic oligomer that might be the cause of beta-cell loss that leads to late stage type 2 diabetes.  This talk will also report images collected using 2D White-Light Microscopy, which is an imaging variant of 2D spectroscopy, on two singlet fission materials. Couplings between molecules have revealed structural ensembles that enhance singlet fission. The goal of this talk is to provide an introduction to 2D spectroscopy and imaging along with some examples of exciting science.

报告人简介

Martin T. Zanni is the Meloche-Bascom Professor of Chemistry at the University of Wisconsin-Madison. He received his PhD from the University of California-Berkeley, working with Dan Neumark, and was an NIH Postdoctoral Fellow at the University of Pennsylvania with Robin Hochstrasser. He is one of the early pioneers of 2D IR spectroscopy and has made many technological innovations that has broadened the capabilities and scope for a wide range of multidimensional spectroscopies and microscopies. He utilizes these new techniques to study topics in biophysics, chemical physics, photovoltaics, and surfaces. He has received many national and international accolades for his research. Notably, he is the only person to have received the ACS Nobel Laureate Signature Award as both a student and a mentor and the first person to receive the Craver, Coblentz, and Lippincott Awards. He founded PhaseTech Spectroscopy Inc., which is the first company to commercialize 2D IR and 2D Electronic spectroscopies.