Abstract

The ability of transition metals to reach high oxidation states, particularly among second- and third-row transition metals, has enabled the development of various catalytic transformations. However, the reactivity and catalytic potential of high-valent intermediates in earth abundant metals, especially first-row late transition metals, remain poorly understood. This talk will highlight recent advances from our group in understanding the synthetic accessibility of high-valent copper complexes and their catalytic relevance. Furthermore, I will discuss our efforts to harness these elusive intermediates to develop new catalytic modes for the synthesis of biologically active molecules and their applications in biomedical imaging.