邀请人：张俊龙

摘要：

Lanthanide for biomedical applications

Ka-Leung Wong

Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR

Email: klwong@hkbu.edu.hk

Lanthanide complexes have been widely utilized as imaging agents such as MRI contrast agents or luminescence labelling for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes or emission quantum efficiency of terbium/europium complexes without sacrificing their stability. This seminar aims to show the strategic design of ligands synthesized for this purpose, provide an overview of our recent development/strategies (i.e. molecular upconversion, thermal sensing and photo-activated drug delivery) in lanthanide-based bioprobes targeting some biological small molecules or proteins for cancer imaging and therapy.