Chiral Bisphosphine Ph-BPE Ligand: A Rising Star in Asymmetric Synthesis
Peifeng Mei, Zibin Ma, Yu Chen, Yue Wu, Wei Hao, Qinghua Fan, and Wen-Xiong Zhang*
Chem. Soc. Rev. 2024, 53, 6735-6778.
https://doi.org/10.1039/d3cs00028a
Chiral 1,2-bis(2,5-diphenylphospholano)ethane (Ph-BPE) is a class of optimal organic bisphosphine ligands with C2-symmetry over time. Ph-BPE with the excellent catalytic performance in asymmetric synthesis has attracted much attention of chemists with increasing popularity and is growing into one of the most commonly used organophosphorus ligands, especially in asymmetric catalysis. Over two hundred examples have sprung up since 2012. This review presents how Ph-BPE is utilized in asymmetric synthesis and how powerful it is as a chiral ligand or even catalyst in a wide range of reactions, including applications in the total synthesis of bioactive molecules.
