We just reported the cryo-EM structure of human TRPV1 in complex with SAF312, elucidating the structural foundation of its antagonistic effects on TRPV1.
Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive anta…
We just reported the cryo-EM structures of hTRPV4 in a complex with two potent small-molecule antagonists A1 and A2, revealing the detailed binding pockets and regulatory mechanisms of TRPV4 gating.
The nonselective calcium-permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (TRPV4) channel regulates various physiological activities. Dysfunction of TRPV4 is linked to many se…
We just reported the chemoenzymatic total synthesis approach of alchivemycin A that combines de novo skeleton construction and late-stage enzymatic oxidation reactions. The work was recently published on Nature Synthesis.
Alchivemycin A belongs to a unique class of polyketide natural products isolated from plant-derived actinomycete Streptomyces. It shows potent antibacterial activity and anti-tumour activity. Howev…
We just investigate the evolutionary origins of the intermolecular DAs in the biosynthesis of Moraceae plant-derived Diels-Alder-type secondary metabolites. The work was recently published on Nature communications.
Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host organisms. Diels-Alderases (DAs), functionally unique en…
We just artificially reconstituted a biosynthetic pathway for the production of baccatin III in tobacco. The work was recently published on Science.
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly of a phenylisose…
We just published the first structure of Fhb7 at 2.41 Å and revealed a unique catalytic mechanism of epoxide opening transformation in GST family proteins.
In the era of global climate change, the increasingly severe Fusarium head blight (FHB) and deoxynivalenol (DON) contamination have caused economic losses and brought food and feed safety concerns. Re…
We just published the first total syntheses of several bis-b-carboline alkaloids, picrasidines G, S, R, and T, and natural product-like derivatives in a divergent manner. The work was recently published on Chemical Science.
Divergent total syntheses of ITHQ-type bis-bcarboline alkaloids by regio-selective formal aza-[4
+ 2] cycloaddition and late-stage C–H
functionalization.
We just published our remarkable work on identification of the potential antidiabetic target microbial DPP4 by microbial-host-isozyme analyses. The work was recently published on Science.
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
We just published our remarkable biosynthesis work on enzyme-catalyzed intermolecular [4+2] cycloaddition. The work was recently published on Nature Chem.
