Natural products have played a crucial role in the development of new therapeutic agents. However, the target identification for natural products is still challenging due to the structural complexity and the lack of efficient biochemical methods. In the previous studies, we have accomplished the collective total syntheses of a number of structurally complex and bioactive […]
Our graduate students Mr. Jianguang Han, Mr. Weilong Liu, Mr. Benke Hong, Ms. Ting Dong, and Mr. Jing Zhang won the “2014 NIBS Excellent Student Award” for their outstanding performance in scientific research.?Big congrats?to all of them!!! Our previous awardees are: 2011 Mr. Chao Li; 2012 Mr. Xiaoming Wang; 2013 Mr. Daohong Liao and Mr. […]
Prof. Lei received the Chinese Chemical Society Young Investigator Award in the National Chemistry Symposium held at Peking University on August 4-8. This is the most prestigious award ?for the young chemist?in China?under the age of 35 who has made outstanding accomplishments in the research of chemistry. During the past 5 years, Prof. Lei and […]
Our paper entitled “Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern” has been published on Nature Communications. In this study, we report a new concept of Functional Group Pairing Pattern Recognition (FGPPR) to facilitate both target-oriented synthesis of complex natural product and diversity-oriented synthesis of natural product-like scaffolds in parallel. […]
Our??paper entitled “Enantioselective Biomimetic Total Syntheses of Kuwanons I and J and?Brosimones A and B” has been published on Angew. Chem. Int. Ed. 2014, DOI:anie.201404499 Abstract: The first enantioselective total syntheses of prenylflavonoid Diels-Alder natural products (-)-kuwanon I, (+)-kuwanon J, (-)-brosimone A and (-)-brosimone B have been accomplished based on a concise synthetic strategy. Key […]
A Roche-PKU joint postdoc fellowship is immediately available in the laboratory of Prof. Xiaoguang Lei at Peking University. Prof. Lei’s group focuses on organic synthesis and chemical biology. One of our major research interests is to discover natural product-based next generation antibiotics. The lack of success in mining synthetic compounds for leads for new antimicrobial […]
Dr. Xiaoguang Lei received the Young Chemical Biologist award of the International Chemical Biology Society based on his contributions to chemical biology.
-
-
-
-
-
-
-
-
-
-
We have discovered a new mode of anticancer action of the natural product ainsliatrimer A
Natural products have played a crucial role in the development of new therapeutic agents. However, the target identification for natural products is still challenging due to the structural complexity and the lack of efficient biochemical methods. In the previous studies, we have accomplished the collective total syntheses of a number of structurally complex and bioactive […]
Jianguang, Weilong, Benke, Ting, and Jing won the 2014 NIBS Excellent Student Award!
Our graduate students Mr. Jianguang Han, Mr. Weilong Liu, Mr. Benke Hong, Ms. Ting Dong, and Mr. Jing Zhang won the “2014 NIBS Excellent Student Award” for their outstanding performance in scientific research.?Big congrats?to all of them!!! Our previous awardees are: 2011 Mr. Chao Li; 2012 Mr. Xiaoming Wang; 2013 Mr. Daohong Liao and Mr. […]
Prof. Lei has received the Chinese Chemical Society Young Investigator Award, Congratulations!
Prof. Lei received the Chinese Chemical Society Young Investigator Award in the National Chemistry Symposium held at Peking University on August 4-8. This is the most prestigious award ?for the young chemist?in China?under the age of 35 who has made outstanding accomplishments in the research of chemistry. During the past 5 years, Prof. Lei and […]
Jing’s work has been published on Nature Communications, Congratulations!
Our paper entitled “Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern” has been published on Nature Communications. In this study, we report a new concept of Functional Group Pairing Pattern Recognition (FGPPR) to facilitate both target-oriented synthesis of complex natural product and diversity-oriented synthesis of natural product-like scaffolds in parallel. […]
Our latest natural product total synthesis on ACIE!
Our??paper entitled “Enantioselective Biomimetic Total Syntheses of Kuwanons I and J and?Brosimones A and B” has been published on Angew. Chem. Int. Ed. 2014, DOI:anie.201404499 Abstract: The first enantioselective total syntheses of prenylflavonoid Diels-Alder natural products (-)-kuwanon I, (+)-kuwanon J, (-)-brosimone A and (-)-brosimone B have been accomplished based on a concise synthetic strategy. Key […]
A Roche sponsored postdoc fellowship is immediately available!
A Roche-PKU joint postdoc fellowship is immediately available in the laboratory of Prof. Xiaoguang Lei at Peking University. Prof. Lei’s group focuses on organic synthesis and chemical biology. One of our major research interests is to discover natural product-based next generation antibiotics. The lack of success in mining synthetic compounds for leads for new antimicrobial […]
Prof. Lei received the 2013 CPA-Servier Young Investigator Award in Medicinal Chemistry
Dr. Xiaoguang Lei received the Young Chemical Biologist award of the International Chemical Biology Society
Dr. Xiaoguang Lei received the Young Chemical Biologist award of the International Chemical Biology Society based on his contributions to chemical biology.
All of Lei group members attended The 24th International Society of Heterocyclic Chemistry Congress in Shanghai, 2013
Our group defended champion successfully on NIBS Fifth Sports Meeting
On April 20th 2013, our group defended champion successfully on NIBS Fifth Sports Meeting.