Lu Research Group
December 2024
Dr. Zhao ruichi, Class of 2019, successfully defended her PHD thesis on December 5th, and will join cofco as a researcher. We will miss her and wish her all the best in the future.
[AWARDS] Shuo Wang Won National Graduate Student Scholarship and the ChemStar Contest of CCME
Sept. 2024
Our 5th year student WANG Shuo was awarded the prestigious 2024 ChemStar Award of CCME based on his recent work on carboxylic acid-catalyzed ring-opening (cascade) polymerization of N-carboxyanhydrides. Great job!
[Graduation] The Lu group celebrates newly minted PhD
June 2024
Dr. Liu Xingyi, Class of 2019, successfully defended his PHD thesis on May 24th, and will join Apricot Capital as a investment manager.
Lu Mingyuan, Class of 2020, received his B.S. degree in chemistry and will continue his PhD research in our group.
We wish all of them great success in their new journey.
[PUBLICATION] Wang Shuo reports the highest molecular weight of polysarsoine work in JACS
Feb. 2024
The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) of N-carboxyanhydride (NCA) is rare and challenging. In the latest work of Wang Shuo, he reports well-controlled ROP of sarcosine NCA (Sar-NCA) catalyzed by various carboxylic acids, which accelerate the polymerization rate up to 50 times, and enables the robust synthesis of pSar with unprecedented ultra-high molecular weight (UHMW) up to 586 kDa (DP ~ 8200) and exceptionally narrow dispersity (Ð) below 1.05. This is the second first-authored research paper of Shuo, keep it on! [Link]
[PUBLICATION] Lu Jianhua’s latest work is published in JACS
Feb. 2024
Biologics, including proteins and antisense oligonucleotides (ASOs), face significant challenges when it comes to achieving intracellular delivery within specific organs or cells through systemic administrations. In this work, we develop a novel approach for delivering proteins and ASOs to liver cells, both in vitro and in vivo, using conjugates that tethering N-acetylated galactosamine (GalNAc)-functionalized, cell-penetrating polydisulfides (PDS). These conjugates hold tremendous potential in overcoming the various biological barriers encountered during systemic and cell-specific delivery of biomacromolecular cargos, opening new avenues for the diagnosis and treatment of a range of liver-targeting diseases. This is the third first-authored JACS paper of Jianhua Lu, great work! [Link]
[News] Lu group members attend the 2023 National Conference of Polymer Science at Wuhan
Sept. 2023
The conference is held biannually and hits a record high of 7000 people. More than 8 people of the Lu group, plus a few alumni, attended the meeting. Dr. Lu organized the Young Investigator Symposium and gave an invited talk in the Symposium of Biomedical Polymer.
[AWARDS] Lu Jianhua Won Prestigious Award
Aug. 2023
Lu Jianhua's PhD Thesis was awarded the prestigious "Elite Youth Spark Award" by the Young Chemists Committee of the Chinese Chemical Society (中国化学会青年化学工作者委员会菁青化学奖 星火奖). She received the award and gave an invited talk in a CCS conference in Changsha.
[Group Activity] Trip to the Huitengxile Grassland in Ulanqab.
July 2023
Where to enjoy summer? Of Course a cool resort. This year’s summer group retreat is a 3-day trip in the Huitengxile Grassland in Ulanqab to celebrate the 2023 graduation. Look at our smiles!
[Graduation] The Lu group celebrates newly minted PhD and BS
June 2023
Three graduate students successfully defended their PHD theses on May 27th.
Dr. Zhang Zhengchu, Class of 2017, will continue his postdoc research in the group.
Dr. Lu Jianhua (Excellent PhD thesis of PKU) and Dr. Zhang Yi, Class of 2018, will join Dalian Changfeng as a scientist and Jiangsu Xishan Senior High School as a teacher.
Ji Yulong, Class of 2019, received his B.S. degree in chemistry and will pursue PhD in the University of Tokyo at Japan.
We wish all of them great success in their new journey.
[PUBLICATION] Guangqi's paper published in Nature Synthesis
May 2023
In the search for synthetic mimics of proteins, we developed a high-throughput platform utilizing the unique chemistry of selenolate on the side chain of synthetic polypeptides. The method is amenable to automation and with the assists of machine learning, functional polypeptides with desired catalytic activity were identified at an much improved rate and efficiency. Check out the study at [LINK]; please also check out the News covering the story by Nat. Synth. [Link]
